Omega-3 oil containing ophthalmic emulsions
AssigneeAbbott Medical Optics Inc.
InventorZhi-Jian Yu
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Abstract
Disclosed herein are non-irritating ophthalmic emulsion compositions useful for treating ocular disorders including dry eye. More specifically, the ophthalmic compositions disclosed herein combine a high HLB surfactant and a low HLB surfactant together with an omega-3 fatty acid-containing oil having non-polar aliphatic side chains to form a therapeutic non-irritating eye drop.
Claims15
An ophthalmic oil-in-water emulsion composition comprising ophthalmically acceptable omega-3 fatty acid-containing oil wherein said oil comprises only aliphatic side chains free of polar pendent groups, a hydrophilic surfactant having an HLB value greater than 8, hydrophobic non-co-block surfactant having an HLB value less than 8, water;
- and wherein said oil-in-water emulsion composition has an average particle size less than 1 μm in diameter.
An ophthalmic oil-in-water emulsion composition comprising an average particle size less than 1 μm, least one ophthalmically acceptable omega-3 fatty acid-containing oil, a hydrophilic surfactant having an HLB value between approximately 10 and 14 and a hydrophobic non-co-block surfactant having an HLB value between approximately 4 and 6.
An ophthalmic oil-in-water emulsion composition comprising an average particle size less than 0.6 μm and wherein said oil-in-water emulsion consists essentially of water, at least one ophthalmically acceptable omega-3 fatty acid-containing oil, a hydrophilic surfactant having an HLB value between approximately 12 and 14 and a hydrophobic non-co-block surfactant having an HLB value between approximately 4 and 5.
An ophthalmic oil-in-water emulsion composition comprising an average particle size less than 0.6 μm and wherein said oil-in-water emulsion consists essentially of water, at least one ophthalmically acceptable omega-3 fatty acid-containing oil and a hydrophilic surfactant having an HLB value between approximately 10 and 11, a hydrophobic non-co-block surfactant having an HLB value between approximately 4 and 5.
An ophthalmic oil-in-water emulsion composition comprising an average particle size less than 0.6 μm and wherein said oil-in-water emulsion consists essentially of water, flax seed, a hydrophilic surfactant consisting of Lumulse® GRH 25 and a hydrophobic non-co-block surfactant consisting of Brij 93.
An ophthalmic oil-in-water emulsion composition comprising an average particle size less than 0.6 μm and consists essentially of flax seed oil, a hydrophilic surfactant having consisting of Lumulse® GRH 40 or Lumulse® GRH 25, a hydrophobic non-co-block surfactant consisting of Brij 93 or Brij 72 and wherein in said ophthalmic composition further comprises an amount of cyclosporine A effective to relieve dry eye symptoms.
Dependencies are inferred from the claim text.