Method and use of microarray technology and proteogenomic analysis to predict efficacy of human and xenographic cell, tissue and organ transplant

A method of identifying a biomarker that will aid in predicting an outcome of a potential transplant of a cell, tissue or organ into a first transplant recipient, comprising the steps of:

• a) evaluating at least one sample associated with an actual transplant at a plurality of timepoints after transplantation;
• b) identifying at least one biomarker in the sample;
• c) identifying at least one biomarker in at least one pre-transplant sample of a preservation solution in which the cell, tissue, or organ is stored;
• and
• d) correlating the biomarker with at least one clinical outcome for the transplantation.

A method of identifying a biomarker that will aid in predicting an outcome of a transplant of a cell, tissue, or organ into a transplant recipient, comprising the steps of:

• a) evaluating a plurality of samples from a plurality of transplants;
• b) identifying at least one biomarker in the samples;
• and
• c) correlating the biomarker with at least one clinical outcome of the transplant;
• wherein the samples are samples taken from a preservation solution in which the cell, tissue or organ was stored prior to the transplant.

A method of identifying a biomarker that will aid in predicting an outcome of a potential transplant of a cell, tissue or organ into a first transplant recipient, comprising the steps of:

• a) evaluating at least one sample associated with an actual transplant at a plurality of timepoints after transplantation;
• b) identifying at least one biomarker in the sample;
• c) identifying at least one biomarker in at least one pre-transplant sample of a flush solution used to flush the cell, tissue or organ;
• and
• d) correlating the biomarker with at least one clinical outcome for the transplantation.

A method of identifying a biomarker that will aid in predicting an outcome of a transplant of a cell, tissue, or organ into a transplant recipient, comprising the steps of:

• a) evaluating a plurality of samples from a plurality of transplants;
• b) identifying at least one biomarker in the samples;
• and
• c) correlating the biomarker with at least one clinical outcome of the transplant;
• wherein the samples are samples taken from a flush solution used to flush the cell, tissue or organ.