B cell signature associated with tolerance in transplant recipients
AssigneesThe Regents of the University of California, University of Pennsylvania, Emory University
InventorsVicki Seyfert, Adam Asare, Laurence A. Turka, Kenneth Newell
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Abstract
The present invention provides methods for predicting the development of tolerance to a transplant, such as a kidney, using molecular markers that have different expression patterns in tolerant transplant recipients, as compared to non-tolerant or healthy, non-recipient controls.
Claims29
A biomarker array comprising at least one biomarker selected from the group consisting of the biomarkers disclosed in Table X and Table Z.
A method for predicting tolerance in a transplant recipient for the transplant, the method comprising,
- (i) detecting in a biological sample from the transplant recipient the expression level of at least one biomarker selected from the group consisting of the biomarkers disclosed in Table X and Table Z;
- and
- (ii) comparing the expression level of the at least one biomarker with the expression level of the same at least one biomarker from a biomarker control,
- thereby predicting the tolerance of the transplant recipient for the transplant.
A method of determining a course of immunosuppressive therapy for a transplant recipient, said method comprising:
- (i) detecting in a biological sample from the transplant recipient the expression level of at least one biomarker selected from the group consisting of the biomarkers disclosed in Table X and Table Z;
- (ii) comparing the expression level of the at least one biomarker with the expression levels of the same at least one biomarker from a biomarker control;
- (iii) predicting whether the transplant recipient will be tolerant of the transplant based on the comparison in step (ii);
- and
- (iv) adjusting the course of immunosuppressive therapy for the transplant recipient depending on whether the transplant recipient is predicted to be tolerant of the transplant.
A method for predicting tolerance in a transplant recipient for the transplant, the method comprising,
- detecting in a biological sample from the transplant recipient the amount of at least one B cell population in the sample;
- and
- comparing the amount of said at least one B cell population to the amount of the same at least one B cell population in a biological sample from a B cell control,
- wherein the at least one B cell population is selected from:
- total B cells, naïve B cells, memory B cells, transitional B cells, and CD86+ B cells,
- thereby predicting the tolerance of the transplant recipient for the transplant.
Dependencies are inferred from the claim text.