US 2010/0304992 A1 · DIAGNOSIS KIT AND CHIP FOR BLADDER CANCER USING BLADDER CANCER SPECIFIC METHYLATION MARKER GENE

Abstract

The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the invention relates to a kit and nucleic acid chip for diagnosing bladder cancer, which can detect the promoter methylation of a bladder cancer-specific gene, the promoter or exon region of which is methylated specifically in transformed cells of bladder cancer. The use of the diagnostic kit or nucleic acid chip of the invention enables diagnosis of bladder cancer at an early stage of transformation, thus enabling early diagnosis of bladder cancer, and can diagnose bladder cancer in a more accurate and rapid manner compared to a conventional method.

Claims8

Dependent claims

A kit for diagnosing bladder cancer, which comprises the methylated promoter of a bladder cancer marker gene selected from the group consisting of:

(1) CDX2 (NM—001265)—caudal type homeobox transcription factor 2;
(2) CYP1B1 (NM—000104)—cytochrome P450, family 1, subfamily B, polypeptide 1;
(3) VSX1 (NM—199425)—visual system homeobox 1 homolog, CHX10-like (zebrafish);
(4) HOXA11 (NM—005523)—homeobox A11;
(5) T (NM—003181)—T, brachyury homolog (mouse);
(6) TBX5 (NM—080717)—T-box 5;
(7) PENK (NM—006211)—proenkephalin;
(8) PAQR9 (NM—198504)—progestin and adipoQ receptor family member IV;
(9) LHX2 (NM—004789)—LIM Homeobox 2;
and
(10) SIM2 (U80456)—single-minded homolog 2 (Drosophila).

8 more elements

Dependencies are inferred from the claim text.

Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene

Life of this patent

Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene

Life of this patent

Abstract

Claims8