Mechanically actuated diagnostic device
AssigneeThe Trustees of the University of Pennsylvania
InventorsZongyuan Chen, Haim H. Bau, Michael G. Mauk, Xianbao Qiu, Jason Kwa
Life of this patent
Estimating the term…
Abstract
Disclosed are mechanically-actuated devices for transporting fluids within a microfluidic circuit and performing diagnostic operations on a sample. Also disclosed are related methods for performing sample analysis effected by the motion of an actuator proximate to a microfluidic system.
Claims34
A fluid processing system, comprising:
- a first component comprising
- a substrate comprising first and second surfaces;
- a fluid reservoir disposed at the first surface of the substrate,
- a deformable capping layer sealing the fluid reservoir,
- the deformable capping layer being capable of deformation so as to reduce the volume within the fluid reservoir;
- a reservoir aperture capable of placing the fluid reservoir into fluid communication with the environment exterior to the first component;
- a sealant layer sealing at least a portion of the reservoir aperture against the environment exterior to the first component;
- and
- a second component comprising a substrate comprising a fluidic element,
- the second component being capable of orientation relative to the first component such that fluidic clement of the second component is placed into fluid communication with the fluid reservoir of the first component.
(canceled)
(canceled)
-12. (canceled)
(canceled)
(canceled)
(canceled)
(canceled)
-22. (canceled)
-27. (canceled)
A sample processing system, comprising:
- a component comprising a fluidic element sealed by a deformable sealing layer;
- and
- a moveable actuator residing proximate to the component,
- at least a portion of the actuator capable of motion relative to the component,
- the actuator comprising one or more actuator portions capable of actuating at least one fluidic element,
- the one or more actuator portions of the actuator being arranged such that movement of the actuator effects a prescribed sequence of actuations of the deformable sealing layer, of one or more fluidic elements, or both, and
- movement of the actuator being capable of effecting fluid motion within at least a portion of the component.
(canceled)
(canceled)
-44. (canceled)
-52. (canceled)
-72. (canceled)
A method for analyzing a sample, comprising:
- placing the sample into a component comprising two or more fluidic elements in fluid communication with one another,
- the one or more fluidic elements being surmounted by a deformable layer;
- controllably subjecting at least a portion of the sample to one or more processing steps effected by the movement of an actuator relative to the first substrate,
- the actuator comprising one or more physical features arranged so as to effect a predetermined schedule of processing steps when the actuator is moved relative to the component,
- one or more of the processing steps comprising transport of the sample from one fluidic element to another, and
- analyzing the sample for the presence of one or more analytes.
-82. (canceled)
Dependencies are inferred from the claim text.