Use of the alpha chain of brain spectrin and fragments thereof, for diagnosing cerebral diseases
AssigneesInstitut Pasteur, Universite Pierre Et Marie Courie (Paris 6)
InventorsSylviane Pied, Vincent Guiyedi, Pierre-Andre Cazenave, Maryvonne Kombila, Youri Chanseaud
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Abstract
The present invention pertains to a method for in vitro prognosticating and/or diagnosing cerebral cerebral malaria, wherein said method comprises a step of detecting non-erythroid spectrin or fragments thereof, and/or antibodies directed against non-erythroid spectrin, in a biological sample. Reagents and kits for performing this method are also disclosed.
Claims36
A method for in vitro prognosticating and/or diagnosing cerebral malaria, characterized in that it comprises a step of detecting in a biological sample non-erythroid spectrin or fragments thereof, and/or antibodies directed against non-erythroid spectrin.
A prognostic and/or diagnostic marker of cerebral malaria comprising antibodies specific for the α chain of non-erythroid spectrin.
A prognostic and/or diagnostic marker of cerebral malaria comprising the α chain of non-erythroid spectrin or of a fragment thereof.
25-28. (canceled)
A kit for establishing a prognosis and/or a diagnosis of cerebral malaria, characterized in that it comprises at least one antigenic molecule derived from the α chain of non-erythroid spectrin.
Dependencies are inferred from the claim text.