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US 2010/0304402 A9Published application
Chimeric human sweet-umami and umami-sweet taste receptors
AssigneeSenomyx, Inc.
InventorsXiaodong Li, Feng Zhang, Hong Xu, Qing Li
Life of this patent
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AssigneeSenomyx, Inc.
InventorsXiaodong Li, Feng Zhang, Hong Xu, Qing Li
Estimating the term…
This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.
A hybrid taste receptor comprising the extracellular domain of one human T1R or a portion thereof and the transmembrane domain of another T1R or a portion thereof.
The chimeric sweet-umami taste receptor identified as hT1R2-1 contained in SEQ ID NO:2.
The chimeric umami-sweet receptor identified as hT1R1-2 contained in SEQ ID NO:4.
A chimeric taste receptor comprising a human T1R1 extracellular domain or a portion or variant thereof and a human T1R2 transmembrane domain or a portion or variant thereof.
A chimeric taste receptor comprising a rodent T1R1 extracellular domain or a portion or variant thereof and a rodent T1R2 transmembrane domain or a portion or variant thereof.
A chimeric taste receptor comprising a human T1R2 extracellular domain or a portion or variant thereof and a human T1R1 transmembrane domain or a portion or variant thereof.
A chimeric taste receptor comprising a rodent T1R2 extracellular domain or a portion or variant thereof and a rodent T1R1 transmembrane domain or a portion or variant thereof.
Dependencies are inferred from the claim text.