Biomarker For Successful Aging Without Cognitive Decline
AssigneeMedical College of Georgia Research Institute, Inc.
InventorShirley E. Poduslo
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Abstract
Methods and compositions for determining whether a subject will age without developing cognitive decline are provided. An exemplary method includes detecting one or more allelic variants in a gene encoding low density lipoprotein-related protein 1B. In a preferred embodiment, the detecting step is accomplished by contacting a sample obtained from the subject with a probe that forms a detectable complex with a nucleic acid in the sample containing an allelic variant indicative of aging without developing cognitive decline, wherein detection of the allelic variant in the sample indicates that the subject will age without developing cognitive decline.
Claims16
A method for determining whether a subject will age without developing cognitive decline comprising detecting one or more allelic variants in a gene encoding low density lipoprotein-related protein 1B by contacting a sample obtained from the subject with a probe that forms a detectable complex with a nucleic acid in the sample containing an allelic variant indicative of aging without developing cognitive decline, wherein detection of the allelic variant in the sample indicates that the subject will age without developing cognitive decline.
A computer-implemented system for determining whether a subject will age without cognitive decline comprising
- means for determining the presence of one or more allelic variants in a gene encoding low density lipoprotein-related protein 1B from a sample obtained from a subject, wherein the one or more allelic variants are selected from the group consisting of rs12474609, rs10201482, and rs980286, and
- means for communicating the detected allelic variants.
Dependencies are inferred from the claim text.