Peptide compounds for detecting or inhibiting sars coronavirus and application thereof
AssigneeElectronics and Telecommunications Research Institute
InventorsSoo-Hyung LEE, Hyo-Bong Hong, Tao-Wan Kim, Myung-Ae Chung, Sung-Woo Sohn, Seoung-Min Yoo
Life of this patent
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Abstract
Disclosed herein are peptide compounds and the application thereof to the detection and inhibition of SARS coronavirus. Composed of dipeptides, the compounds for detecting and inhibiting SARS coronavirus can be readily synthesized and produced at low cost. In addition, they can be stored safely for a long period of time. The dipeptide compounds are useful as inhibitors of SARS coronavirus as well as acting as excellent capturing materials of SARS coronavirus.
Claims12
An agent for capturing and inhibiting SARS coronavirus, comprising a compound represented by the following Chemical Formula 1:
- wherein
- X and X′ are independently H;
- a functional group selected from a group consisting of biotin, streptavidin and avidin;
- or a functional moiety composed of the functional group and a linker which links the functional group to the backbone of the compound of Chemical Formula 1 therethrough;
- n is 0 or 1;
- and
- R and R′ are independently selected from a group consisting of —H, —CH3, —CH(CH3)2, —CH2CH(CH3)25—CHCH3CH2CH3, —CH2OH, —CHOHCH3, —CH2SH, —(CH2)2SCH3, —CH2COOH, —CH2CONH2, —(CH2)2COOH, —(CH2)2CONH2, —(CH2)3CH2NH2, —(CH2)3NHCNHNH2,
- CH2CH2CH2— and —CH2SSCH2—.
A compound for capturing and inhibiting SARS coronavirus, represented by the following Chemical Formula:
- wherein
- X and X′ are independently H;
- a functional group selected from a group consisting of biotin, streptavidin and avidin;
- or a functional moiety composed of the functional group and a linker which links the functional group to the backbone of the compound of Chemical Formula 1 therethrough;
- n is 0 or 1;
- and
- R and R′ are independently selected from a group consisting of —H, —CH3, —CH(CH3)2, —CH2CH(CH3)2, —CHCH3CH2CH3, —CH2OH, —CHOHCH3, —CH2SH, —(CH2)2SCH3, —CH2COOH, —CH2CONH2, —(CH2)2COOH, —(CH2)2CONH2, —(CH2)3CH2NH2, —(CH2)3NHCNHNH2,
- CH2CH2CH2— and —CH2SSCH2—.
A method for detecting SARS coronavirus, comprising:
- contacting a compound, represented by the following Chemical Formula 1, with a sample from a subject:
- wherein
- X and X′ are independently H;
- a functional group selected from a group consisting of biotin, streptavidin and avidin;
- or a functional moiety composed of the functional group and a linker which links the functional group to the backbone of the compound of Chemical Formula 1 therethrough;
- n is 0 or 1;
- and
- R and R′ are independently selected from a group consisting of —H, —CH3, —CH(CH3)2, —CH2CH(CH3)2, —CHCH3CH2CH3, —CH2OH, —CHOHCH3, —CH2SH, —(CH2)2SCH3, —CH2COOH, —CH2CONH2, —(CH2)2COOH, —(CH2)2CONH2, —(CH2)3CH2NH2, —(CH2)3NHCNHNH2,
- CH2CH2CH2— and —CH2SSCH2—.
Dependencies are inferred from the claim text.