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US 2010/0304355 A1Published application
Devices and methods for pharmacokinetic-based cell culture system
OwnerMichael Shuler, Gregory T. Baxter +3inventors
InventorsMichael Shuler, Gregory T. Baxter, Aaron Sin, Robert Andrew Harrison, Scott Meyers
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Abstract
Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
Claims51
A pharmacokinetic-based microscale culture device, comprising:
- a first microscale chamber dimensioned to maintain biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, wherein the first microscale chamber comprises a first inlet and a first outlet for flow of fluid;
- a second microscale chamber dimensioned to maintain biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, wherein the second microscale chamber comprises a second inlet and a second outlet for flow of fluid;
- a microfluidic channel interconnecting the first and second microscale chambers wherein the microfluidic channel is dimensioned to transport the fluid;
- and
- a heating element that is configured to maintain a desired temperature under a condition of flow of the fluid.
2 more elements
A device comprising:
- at least one microscale feature dimensioned to maintain biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter found in vivo;
- and
- a heating element configured to control, adjust, or maintain temperature.
A method of culturing biological material comprising:
- maintaining biological material with a first microscale chamber under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, wherein the first microscale chamber comprises a first inlet and a first outlet for flow of fluid;
- maintaining biological material with a second microscale chamber under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, wherein the second microscale chamber comprises a second inlet and a second outlet for flow of fluid;
- interconnecting the first and second microscale chambers with a microfluidic channel wherein the microfluidic channel is dimensioned to transport the fluid;
- and
- maintaining a desired temperature under a condition of flow of the fluid.
2 more elements
A method comprising:
- maintaining biological material with at least one microscale feature under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter found in vivo;
- and
- controlling, adjusting, or maintaining temperature with a heating element.
A device comprising:
- means for maintaining biological material with at least one microscale feature under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter found in vivo;
- and
- means for adjusting the temperature with a heating element.
A method comprising:
- forming a microscale feature that is dimensioned to maintain biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter found in vivo;
- and
- adding, forming, or providing for a heating element.
A method comprising:
- means for forming a microscale feature that is dimensioned to maintain biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter found in vivo;
- and
- means for adding, forming, or providing for a heating element.
A device comprising:
- a microscale chamber comprising a biological material and a geometry simulating parts of a living body, wherein the microscale chamber is configured to substantially mimic at least one measurable in vivo condition in vivo;
- and
- a heating element configured to control, adjust, or maintain temperature.
Dependencies are inferred from the claim text.