Methods of improving a genomic marker index of dairy animals and products
AssigneePfizer Inc.
InventorsFengxing Du, Nicholas J. Nissing, Michael D. Grosz, Michael M. Lohuis
Life of this patent
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Abstract
The present invention provides methods for improving desirable dairy traits through the use of a genomic marker index. Also provided are methods for determining an animal's genotype with respect to multiple markers used in calculation of the genomic marker index. The invention also provides methods for selecting or allocating animals for predetermined uses, for picking potential parent animals for breeding, and for producing improved dairy products.
Claims22
A method for allocating a bovine animal for use according to the animal's genomic marker index, the method comprising:
- a. determining the animal's genotype at ten or more locus/loci;
- wherein at least one locus contains a single nucleotide polymorphism (SNP), having at least two allelic variants;
- and wherein at least 10 SNPs are:
- selected from the SNPs described in Table 1 and the Sequence Listing;
- b. analyzing the determined genotype of at least one evaluated animal at 10 or more SNPs selected from the SNPs described in Table 1 and the Sequence Listing;
- and/or
- c. calculating a genomic marker index using Equation 2 and the weightings found in Table 1:
- GMI
- ik
- =
- ∑
- j
- =
- 1
- 121
-
- W
- ij
-
- (
- G
- jk
- )
- [
- Equation
-
-
- 2
- ]
- wherein Gjk is the genotype of jth marker of animal k and Wij(Gjk) is the weight of genotype Gjk at the jth marker for index i.
- d. allocating the animal for use based on its determined genomic marker index.
The method of 2 wherein the animal's genotype is evaluated at 500 or more loci.
A method for selecting a potential parent bovine animal based on a genomic marker index, comprising:
- a. determining at least one potential parent animal's genotype at 10 or more genomic loci;
- wherein at least one locus contains a single nucleotide polymorphism (SNP) that has at least two allelic variants, and wherein at least ten SNPs are selected from the SNPs described in Table 1 and the Sequence Listing;
- b. analyzing the determined genotype of at least one evaluated animal for ten or more SNPs selected from the SNPs described in Table 1;
- c. calculating a genomic marker index using weightings found in Table 1, and the following equation:
- GMI
- ik
- =
- ∑
- j
- =
- 1
- 121
-
- W
- ij
-
- (
- G
- jk
- )
- [
- Equation
-
-
- 2
- ]
- wherein Gjk is the genotype of jth marker of animal k and Wij(Gjk) is the weight of genotype Gjk at the jth marker for index i.
- d. allocating at least one animal for breeding use based on its genotype.
22-56. (canceled)
Dependencies are inferred from the claim text.