N-halamine formulations with enhanced antimicrobial activity
AssigneeAlcon Research, Ltd.
InventorsThomas Christopher Carey, Nissanke L. Dassanayake, Ronald L. Schlitzer, Howard Allen Ketelson
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Abstract
The present invention relates to antimicrobial formulations comprising an N-halamine and a quantity of sodium chlorite sufficient to enhance the antimicrobial efficacy of the N-halamine. The present invention is further directed to formulations for disinfecting a contact lens comprising an N-halamine and a quantity of sodium chlorite sufficient to enhance the antimicrobial efficacy of the N-halamine.
Claims12
A sterile, aqueous ophthalmic composition comprising an N-halamine of Formula (I):
- where R═H,
- n=1−10;
- X═Cl, Br, or I;
- R1, R2, and R3 are, independently, H, CH3, C2H5, or C3H7;
- R4, R5, R6, and R7 are, independently, H, CH3, C2H5, C3H7 or t-butyl;
- or a pharmaceutically acceptable salt thereof, and a quantity of sodium chlorite sufficient to enhance the antimicrobial efficacy of the N-halamine and a pharmaceutically acceptable vehicle therefor.
A disinfecting tablet soluble in aqueous solution, said tablet comprising an N-halamine of Formula (I)
- where R═H,
- n=1−10;
- X═Cl, Br, or I;
- R1, R2, and R3 are, independently, H, CH3, C2H5, or C3H7;
- R4, R5, R6, and R7 are, independently, H, CH3, C2H5, C3H7 or t-butyl;
- or a pharmaceutically acceptable salt thereof, and
- a quantity of sodium chlorite sufficient to enhance the antimicrobial efficacy of the N-halamine when dissolved in aqueous solution and a pharmaceutically acceptable vehicle therefor.
Dependencies are inferred from the claim text.