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AssigneesHannam University Institute dor Industry- Academia Corporation, Korea Umited Pharm, Inc.
InventorsSoon Hong Yuk, Keun Sang Oh, Won Tae Jung, Youn Woong Choi, Sang Min Cho, Dae Chul Ha, Do Hyung Kim, Seong Woo Ahn, Jeong Hyun Choi
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Disclosed are biocompatible polymeric nanoparticles for drug delivery and a method for preparing the same. They can be prepared by mixing a tri-block copolymer, PEG, and a drug at a predetermined temperature to give a homogeneous polymeric mixture; solidifying the homogeneous polymeric mixture at room temperature; and dissolving the solidified polymeric mixture in an aqueous solution. Based on a polymer melting process, the method makes it easy to produce poloxamer nanoparticles at low cost. The nanoparticles show desired particle sizes suitable for use in drug delivery and a uniform particle size distribution. Consisting of a bilayer structure, the nanoparticles can contain sparingly soluble drugs. Also, the nanoparticles contain no organic solvents and are thus safe to the body because they are free of organic solvent residuals. Further, after being administered into the body, the nanoparticles with a high content of sparingly soluble drug entrapped therein can safely deliver the drug to target sites and stably release the drug at a controlled rate.
1-21. (canceled)
A method for preparing biocompatible polymeric nanoparticles for drug delivery, comprising the steps of:
The method of claim 28, wherein the tri-block copolymer is mixed with the polyethylene glycol at a mixture ratio ranging from 5:5 to 9:1.
A method for preparing biocompatible polymeric nanoparticle aggregates for drug delivery, comprising the steps of:
A composition comprising biocompatible polymeric nanoparticles for drug delivery, wherein the nanoparticles are prepared by the method comprising the steps of:
A composition comprising biocompatible polymeric nanoparticles for drug delivery, wherein the nanoparticles are prepared by the method comprising the steps of:
Dependencies are inferred from the claim text.