Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds

A bio-adhesive supramacromolecular complex of the general formula:

• wherein R1 is independently selected from the group consisting of alkanes unsubstituted or substituted with alkoxy groups;
• R2 is independently selected from C1-6 alkyl;
• R3 and R4 are independently selected from the group consisting of substituted and unsubstituted aliphatic and aromatic alkyl;
• R5 is independently selected from H or C1-6 alkyl;
• W is a hydrogen-bond accepting functional group-containing entity;
• Y is a carboxylic acid ester or amide linkage;
• R is an independently selected peptide linking group;
• T1, T2, T3 and T4 are independently selected polymer residues;
• and m1, m2, m3, n1 and n2 are integers selected from at least 25;
• and wherein P has a molecular weight of about 1×103 to 1×107 and Q has a molecular weight of about 1×103 to 1×107.

A bio-adhesive supramacromolecular complex of the general formula:

• wherein R1 is an alkyl vinyl ether (C1-C5), ethylene, propylene, isobutylene, butadiene, 1-octadecene, styrene, maleic acid, or maleic anhydride unit;
• W1 and W2 are hydrogen-bond accepting functional group-containing entities selected from vinylpyrrolidone, ethylene oxide, propylene oxide, vinyl acetate, alkoxyl substituted glucopyranose, glucosamine, and acetylglucosamine;
• R2 and R3 are independently selected from unsubstituted alkyl and substituted and unsubstituted aliphatic or aromatic alkyl;
• R4 is a substituted aliphatic or aromatic alkyl;
• Y is a carboxylic acid ester or amide linkage;
• R5 is independently selected from H and C1-6 alkyl;
• RSNO is a primary amine containing S-nitrosothiol of cysteine, γ-Glu-Cys, α-Glu-Cys, glutathione, homoglutathione, hydroxymethyl-glutathione, γ-Glu-Cys-Glu, α-Glu-Cys-Gly, α-Glu-Cys-β-Ala, α-Glu-Cys-Ser, α-Glu-Cys-Glu, other glutathione analogs containing at least one of —SH and —NH2 and —OH functional groups, and one of the following peptides:
• (γ-Glu-Cys)q, (γ-Glu-Cys)q-Gly, (γ-Glu-Cys)q-β-Ala, (γ-Glu-Cys)q-Ser, (γ-Glu-Cys)q-Glu, (α-Glu-Cys)q, (α-Glu-Cys)q-Gly, (α-Glu-Cys)q-β-Ala, (α-Glu-Cys)q-Ser, and (α-Glu-Cys)q-Glu, where q=2-11;
• T1, T2, T3 and T4 are independently selected polymer residues;
• m1, m2, m3, n1, n2, and n3 are integers greater than 25.