Graft materials and methods for staged delivery of bioactive components
AssigneeCook Biotech Incorporated
InventorAbram D. Janis
Life of this patent
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Abstract
Described, in certain aspects of the invention, are multilaminate medical graft products, as well as methods for preparing and using the same. An illustrative multilaminate medical graft product of the invention comprises a first layer of remodelable extracellular matrix (ECM) material bonded to a second layer of remodelable ECM material, wherein the first material layer is enriched with a growth factor relative to the second material layer. Such a remodelable ECM material may be comprised of submucosa from a warm-blooded vertebrate, for example, porcine small intestinal submucosa (SIS).
Claims23
A multilaminate medical graft product, comprising:
- a first isolated tissue layer of remodelable extracellular matrix tissue material, said first tissue layer isolated from a biological tissue source;
- a second isolated tissue layer of remodelable extracellular matrix tissue material, said second tissue layer isolated from a biological tissue source, wherein said second tissue layer is bonded to said first tissue layer;
- and
- a first bioactive component,
- wherein said first isolated tissue layer is enriched with said first bioactive component relative to said second isolated tissue layer.
A method of preparing a multilaminate medical graft product, said method comprising the steps of:
- providing a first isolated tissue layer of remodelable extracellular matrix tissue material, said first tissue layer isolated from a biological tissue source;
- providing a second isolated tissue layer of remodelable extracellular matrix tissue material, said second tissue layer isolated from a biological tissue source, said first isolated tissue layer being enriched with a bioactive component relative to said second isolated tissue layer;
- and
- bonding said first isolated tissue layer to said second isolated tissue layer.
A medical product, comprising:
- a multilaminate medical graft product enclosed within a sealed package, said graft product comprising:
- a first isolated tissue layer of remodelable extracellular matrix tissue material, said first tissue layer isolated from a biological tissue source;
- a second isolated tissue layer of remodelable extracellular matrix tissue material, said second tissue layer isolated from a biological tissue source, wherein said second tissue layer is bonded to said first tissue layer;
- and
- a first bioactive component,
- wherein said first isolated tissue layer is enriched with said first bioactive component relative to said second isolated tissue layer.
A method of tissue grafting, comprising:
- applying to tissue of a patient a multilaminate medical graft product comprising:
- a first isolated tissue layer of remodelable extracellular matrix tissue material, said first tissue layer isolated from a biological tissue source;
- a second isolated tissue layer of remodelable extracellular matrix tissue material, said second tissue layer isolated from a biological tissue source, wherein said second tissue layer is bonded to said first tissue layer;
- and
- a first bioactive component,
- wherein said first isolated tissue layer is enriched with said first bioactive component relative to said isolated tissue layer.
A method of treating an open cutaneous wound on a patient, comprising:
- applying to the wound a multilaminate medical graft product, comprising:
- a first isolated tissue layer of remodelable extracellular matrix tissue material, said first tissue layer isolated from a biological tissue source;
- a second isolated tissue layer of remodelable extracellular matrix tissue material, said second tissue layer isolated from a biological tissue source, wherein said second tissue layer is bonded to said first tissue layer;
- and
- a first bioactive component,
- wherein said first isolated tissue layer is enriched with said first bioactive component relative to said second isolated tissue layer.
A multilayer medical graft product, comprising:
- a first isolated tissue layer of remodelable extracellular matrix tissue material isolated from a biological tissue source, said first isolated tissue layer comprising at least 80% by weight collagen on a dry weight basis and retaining uniaxial or multiaxial oriented fibers from said biological tissue source;
- a second isolated tissue layer of remodelable extracellular matrix tissue material isolated from a biological tissue source, said second isolated tissue layer comprising at least 80% by weight collagen on a dry weight basis and retaining uniaxial or multiaxial oriented fibers from said biological tissue source;
- and
- a first bioactive component, wherein said first isolated tissue layer is enriched with said first bioactive component relative to said second isolated tissue layer.
Dependencies are inferred from the claim text.