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US 2010/0303883 A1Published application
Polymeric drug delivery systems and thermoplastic extrusion processes for producing such systems
AssigneeAxxia Pharmaceuticals, LLC
InventorsWayne C. Pollock, Stuart A. Grossman, Albert H. Owens
Life of this patent
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Abstract
Implants are disclosed for delivery of therapeutic agents such as opioids and the manufacture and uses of such implants.
Claims36
A subcutaneous delivery system comprising:
- i) a biocompatible thermoplastic polymer matrix,
- ii) a therapeutic agent embedded homogeneously in said matrix, and
- iii) a biocompatible drug impermeable thermoplastic polymer coating said matrix,
- wherein said delivery system has a geometry such that there is an external coated wall and an internal uncoated wall forming an opening for release of said therapeutic agent, and the distance between the uncoated wall and the coated wall opposite the uncoated wall is substantially constant throughout the delivery system.
1 more element
A subcutaneous delivery system comprising
- i) an EVA polymer matrix,
- ii) a therapeutic agent embedded homogeneously in said matrix,
- iii) a biocompatible drug impermeable EVA polymer coating said matrix
- wherein said delivery system has a geometry such that there is an external coated wall and an internal uncoated wall forming an opening for release of said therapeutic agent, and the distance between the uncoated wall and the coated wall opposite the uncoated wall is substantially constant throughout the delivery system.
1 more element
A subcutaneous delivery system comprising
- i) a biocompatible thermoplastic urethane polymer matrix,
- ii) a therapeutic agent embedded homogeneously in said matrix,
- iii) a biocompatible drug impermeable thermoplastic urethane polymer coating said matrix,
- wherein said delivery system has a geometry such that there is an external coated wall and an internal uncoated wall forming an opening for release of said therapeutic agent, and the distance between the uncoated wall and the coated wall opposite the uncoated wall is substantially constant throughout the delivery system.
1 more element
A method of producing a subcutaneous implant comprising the steps of:
- i) forming a matrix polymer sheet by hot melt compounding a first thermoplastic polymeric resin with a therapeutic agent,
- ii) die cutting said sheet to form polymer matrix, and
- iii) coating said polymer matrix with a second thermoplastic polymeric resin.
A method of producing a subcutaneous implant delivery system comprising the steps of:
- i) hot melt extrusion of a first thermoplastic polymeric resin with a therapeutic agent to form a polymer matrix in a cylindrical shape,
- ii) powder coating and thermal fusing a second thermoplastic polymeric resin on said polymer matrix to form a therapeutic agent impermeable coating, and
- iii) forming an uncoated channel in said implant.
A method of producing a subcutaneous implant delivery system having an uncoated central channel comprising the steps of:
- co-extruding of a first thermoplastic polymeric resin and a therapeutic agent and a second thermoplastic polymeric resin into a multiple cavity die to form a coated polymer matrix.
Dependencies are inferred from the claim text.