SILANE-FUNCTIONALIZED HYDROPHOBIC a(1-4)GLUCOPYRANOSE POLYMERS AND POLYMERIC MATRICES FOR IMPLANTATION OR INJECTION
AssigneeSurModics, Inc.
InventorsAleksey V. Kurdyumov, Nathan A. Lockwood, Joram Slager, Dale G. Swan, Robert Hergenrother
Life of this patent
Estimating the term…
Abstract
Silane-functionalized hydrophobic α(1→4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic α(1→4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.
Claims20
A hydrophobic derivative of a natural biodegradable polysaccharide comprising:
- a poly-α(1→4)glucopyranose portion;
- hydrophobic groups pendent from the poly-α(1→4)glucopyranose portion, the groups comprising a hydrocarbon segment comprising two or more carbon atoms;
- and
- one or more silyl ether groups pendent from the poly-α(1→4)glucopyranose portion.
An implantable or injectable biomedical article, the article comprising a polymeric matrix comprising:
- formula V:
- wherein G represents a monomeric unit of a hydrophobic α(1→4)glucopyranose polymer, Q represents an atom of a material that is not the hydrophobic α(1→4)glucopyranose polymer, R12 and R13 are independently selected from R4 and OR4, wherein R4 includes a hydrocarbon group, such as a C1-C6-containing hydrocarbon group, or more specifically a linear or branched C1-C6 alkyl group, and R14 is a group linking the silane atom to the monomeric unit;
- or formula VI:
- wherein G1 and G2 represent monomeric units of different hydrophobic α(1→4)glucopyranose polymers, R15, R16, R17, and R18 are independently selected from R4 and OR4, wherein R4 includes a hydrocarbon group, such as a C1-C6-containing hydrocarbon group, or more specifically a linear or branched C1-C6 alkyl group, and R19 and R20 are groups linking the silane atoms to the monomeric units;
- or
- both formula V and formula VI.
Dependencies are inferred from the claim text.