Vaccination method
AssigneeDuke University
InventorsBarton F. Haynes, Hua-Xin Liao
Life of this patent
Estimating the term…
Abstract
The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to methods of effecting local and systemic immunization against HIV while protecting cells (e.g., mucosal dendritic and epithelial cells) from viral challenge. The invention further relates to compounds (e.g., nucleic acids encoding polypeptides that can elicit an immune response and/or protect cells against viral challenge) and compositions suitable for use in such methods.
Claims11
An isolated immunogen comprising an amino acid sequence as set forth in FIGS. 1-18.
A composition comprising at least 1 immunogen comprising an amino acid sequence as set forth in FIGS. 1-18 and a carrier.
An isolated nucleic acid encoding an immunogen comprising an amino acid sequence as set forth in FIGS. 1-18.
A minigene comprising a nucleic acid sequence encoding an immunogen as set forth in FIGS. 1-18.
A method of inducing an immune response in a patient and protecting said patient from viral challenge comprising administering to said patient an amount of an immunogen comprising an amino acid sequence as set forth in FIGS. 1-18 sufficient to induce said immune response and introducing into cells of said patient a nucleic acid sequence encoding a membrane-anchored peptide that inhibits human immunodeficiency virus-1 (HIV-1) entry into cells under conditions such that said nucleic acid sequence is expressed and said membrane-anchored peptide is displayed on the surface of said cells whereby entry of HIV-1 into said cells is inhibited and said patient is thereby protected from viral challenge.
Dependencies are inferred from the claim text.