Method for Identifying a MHC Class H-Dependent Tumor Associated T Helper Cell Antigen
OwnerDorothee Herlyn, Rajasekharan Somasundaram +1inventors
InventorsDorothee Herlyn, Rajasekharan Somasundaram, Rolf K. Swoboda
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Abstract
The present invention is a method for identifying MHC class II-dependent disease-associated antigens. The instant method involves expressing a library of disease-derived proteins in lytic bacteriophage for subsequent presentation by antigen presenting cells to T helper cells. Disease-associated antigens are provided as are the use of such antigens in vaccines for inducing an immune response and preventing or treating disease. Moreover, the present invention provides antibodies, which specifically bind to MHC class II-dependent disease-associated antigens or epitope peptides thereof, and their diagnostic and therapeutic use.
Claims13
A method for identifying a MHC class II-dependent disease-associated T helper cell antigen comprising expressing a library of disease-derived proteins in lytic bacteriophage;
- presenting antigens of the library of disease-derived proteins on the surface of MHC class II-positive antigen presenting cells (APC);
- contacting the APC with T helper cells and determining T helper cell recognition, wherein the recognition by a T helper cells is indicative of said APC presenting a MHC class II-dependent disease-associated T helper cell antigen.
Dependencies are inferred from the claim text.