Methods for the treatment of il-1beta related diseases
AssigneeXoma Technology Ltd.
InventorsAlan M. Solinger, Patrick J. Scannon, Robert J. Bauer, David Alleva
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Abstract
Disclosed are methods for the treatment and/or prevention of Type 2 diabetes, insulin resistance and disease states and conditions characterized by insulin resistance, obesity, hyperglycemia, hyperinsulinemia and Type 1 diabetes, comprising administering to a subject an effective amount of anti-IL-1β antibody or fragment thereof.
Claims77
A method of treating in a human, a disease or condition selected from the group consisting of Type 2 diabetes, insulin resistance, decreased insulin production, hyperglycemia, hyperinsulinemia, Type 1 diabetes and obesity, the method comprising administering an anti-IL-1β antibody or fragment thereof to the human.
The use of an anti-IL-1β antibody or fragment thereof which has a lower IC50 than an IL-1β receptor antagonist in a human whole blood IL-1β inhibition assay that measures IL-1β induced production of IL-8, in the manufacture of a composition for use in the treatment of Type 2 diabetes, hyperglycemia, hyperinsulinemia, obesity, decreased insulin production, and insulin resistance.
Dependencies are inferred from the claim text.