US 2010/0303805 A1Published application

Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases

AssigneeBoard of Regents, The University of Texas System

InventorsMuralidhar Reddy Moola, Dwight German, Steven Connell, Rosemary Wilson, Johnnie Wilson, Thomas Kodadek

Life of this patent

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Abstract

The present invention provides for the identification of individuals having neurodegenerative diseases (ND). Peptoids recognized by Parkinson's Disease- and Alzheimer's Disease-specific antibodies are identified, allowing one to diagnose or predict ND in subjects.

Claims54

Dependent claims

A method of detecting antibodies in an antibody-containing sample comprising:

(a) contacting an antibody-containing sample with a support having affixed thereto a peptoid having:
(i) the formula (1A):
wherein, R1 and R4 are independently selected from the group consising of from hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R2, R3 and R5 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(ii) formula (1B):
wherein, R6 is selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R7 and R8 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(iii) formula (1C):
wherein, R9, R11, and R13 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R10, R12 and R14 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(iv) formula (1D):
wherein, R17-R20 and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21, R22 and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl
(v) formula (1D):
wherein, R17-R20, R23, and R24 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21 and R22 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
or
(vi) formula (1D):
wherein, R17, R19, R20, and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R18, R21, and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
and
wherein Z is coupling group;
L is an optional linker moiety, M is a substrate or support;
and m, n, o, and/or p is 0-6;
and
(b) detecting antibodies bound to said peptoid.

371 more elements

A method of detecting antibodies in an antibody-containing sample comprising:

(a) contacting an antibody-containing sample with a support having affixed thereto a peptoid having:
(i) the formula (2A):
wherein, R27 is an alkylaryl group or methylbenzyl group;
and
wherein, R25, R26, R28-R32 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
or
(ii) formula (2B):
wherein, R34 is an alkylamine or N-butylamine;
wherein, R35 is an alkenyl, such as an allyl group, and
wherein, R33, R36 and R38-R40 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
and
wherein, Z is coupling group;
L is an optional linker moiety, M is a substrate or support;
and m, n, o, and/or p is 0-6;
and
(b) detecting antibodies bound to said peptoid.

119 more elements

A method of treating a subject suspected of having a neurodegenerative disease (ND) comprising:

(a) contacting an antibody-containing sample from said subject with one or more supports having affixed thereto a peptoid comprising:
(i) the formula (1A):
wherein, R1 and R4 are independently selected from the group consising of from hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R2, R3 and R5 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(ii) formula (1B):
wherein, R6 is selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R7 and R8 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(iii) formula (1C):
wherein, R9, R11, and R13 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R10, R12 and R14 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(iv) formula (1D):
wherein, R17-R20 and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21, R22 and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(v) formula (1D):
wherein, R17-R20, R23, and R24 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21 and R22 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl. or
(vi) formula (1D):
wherein, R17, R19, R20, and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R18, R21, and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(vi) the formula (2A):
wherein, R27 is an alkylaryl group or methylbenzyl group;
and
wherein, R25, R26, R28-R32 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
or
(vii) formula (2B):
wherein, R34 is an alkylamine or N-butylamine;
wherein, R35 is an alkenyl, such as an allyl group, and
wherein, R33, R36 and R38-R40 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
and
wherein Z is coupling group;
L is an optional linker moiety, M is a substrate or support;
and m, n, o, and/or p is 0-6;
and
(b) detecting antibodies bound to said peptoids;
and
(c) making a treatment decision based on the result of step (b).

487 more elements

A kit for detecting antibodies that are indicative of a neurodegenerative disease, the kit comprising one or more peptoids comprising:

(i) the formula (1A):
wherein, R1 and R4 are independently selected from the group consising of from hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R2, R3 and R5 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(ii) formula (1B):
wherein, R6 is selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R7 and R8 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(iii) formula (1C):
wherein, R9, R11, and R13 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R10, R12 and R14 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(iv) formula (1D):
wherein, R17-R20 and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21, R22 and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(v) formula (1D):
wherein, R17-R20, R23, and R24 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21 and R22 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
or
(vi) formula (1D):
wherein, R17, R19, R20, and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R18, R21, and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(vii) the formula (2A):
wherein, R27 is an alkylaryl group or methylbenzyl group;
and
wherein, R25, R26, R28-R32 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
or
(viii) formula (2B):
wherein, R34 is an alkylamine or N-butylamine;
wherein, R35 is an alkenyl, such as an allyl group, and
wherein, R33, R36 and R38-R40 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
and
wherein Z is coupling group;
L is an optional linker moiety, M is a substrate or support;
and m, n, o, and/or p is 0-6.

483 more elements

A method of diagnosing AD in a subject suspected of having alzheimer's disease comprising:

(a) exposing a serum sample from said patient to a microarray comprising a plurality of high-affinity peptoids having:
(i) the formula (1A):
wherein, R1 and R4 are independently selected from the group consising of from hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R2, R3 and R5 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(ii) formula (1B):
wherein, R6 is selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R7 and R8 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(iii) formula (1C):
wherein, R9, R11, and R13 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R10, R12 and R14 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(iv) formula (1D):
wherein, R17-R20 and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21, R22 and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(v) formula (1D):
wherein, R17-R20, R23, and R24 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21 and R22 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
or
(vi) formula (1D):
wherein, R17, R19, R20, and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R18, R21, and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(vii) the formula (2A):
wherein, R27 is an alkylaryl group or methylbenzyl group;
and
wherein, R25, R26, R28-R32 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
or
(viii) formula (2B):
wherein, R34 is an alkylamine or N-butylamine;
wherein, R35 is an alkenyl, such as an allyl group, and
wherein, R33, R36 and R38-R40 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
and
wherein Z is coupling group;
L is an optional linker moiety, M is a substrate or support;
and m, n, o, and/or p is 0-6;
and;
(b) detecting an AD associated antibody 1 bound to high affinity peptoid A;
and, optionally
(c) detecting an AD associated antibody 2 bound to high affinity peptoid B.

488 more elements

A composition comprising a peptoid having the following formula:

(a) the formula (1A):
wherein, R1 and R4 are independently selected from the group consising of from hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R2, R3 and R5 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(b) formula (1B):
wherein, R6 is selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R7 and R8 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(c) formula (1C):
wherein, R9, R11, and R13 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R10, R12 and R14 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(d) formula (1D):
wherein, R17-R20 and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21, R22 and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl
(e) formula (1D):
wherein, R17-R20, R23, and R24 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21 and R22 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
or
(f) formula (1D):
wherein, R17, R19, R20, and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R18, R21, and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
and
wherein Z is coupling group;
L is an optional linker moiety, M is a substrate or support;
and m, n, o, and/or p is 0-6.

368 more elements

An isolated peptoid having the following formula:

(a) the formula (1A):
wherein, R1 and R4 are independently selected from the group consising of from hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R2, R3 and R5 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(b) formula (1B):
wherein, R6 is selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R7 and R8 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(c) formula (1C):
wherein, R9, R11, and R13 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R10, R12 and R14 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(d) formula (1D):
wherein, R17-R20 and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21, R22 and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl
(e) formula (1D):
wherein, R17-R20, R23, and R24 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21 and R22 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
or
(f) formula (1D):
wherein, R17, R19, R20, and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R18, R21, and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
and
wherein Z is coupling group;
L is an optional linker moiety, M is a substrate or support;
and m, n, o, and/or p is 0-6.

368 more elements

Dependencies are inferred from the claim text.

Facts

Application: 12/791,389Filed 1 Jun 2010
Priority: 2 Jun 2009
Published: 2 Dec 2010
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

G01N 33/6896
Related to diseases not provided for elsewhere: neurological disorders, e.g. Alzheimer's disease
A61P 25/28
Drugs for disorders of the nervous system: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents,…
G01N 33/564
Immunoassay; Biospecific binding assay; Materials therefor: for pre-existing immune complex or autoimmune disease , i.e. systemic lupus…
G01N 33/6845
General methods of protein analysis not limited to specific proteins or families of proteins: methods of identifying protein-protein interactions…

Family

Application61/183,260Us provisional application · filed 2 Jun 2009
Application61/318,655Us provisional application · filed 29 Mar 2010
US 9,551,721 B2Related patent
US 2010/0303805 A1This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

A method of detecting antibodies in an antibody-containing sample comprising:

(a) contacting an antibody-containing sample with a support having affixed thereto a peptoid having:
(i) the formula (1A):
wherein, R1 and R4 are independently selected from the group consising of from hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R2, R3 and R5 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(ii) formula (1B):
wherein, R6 is selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R7 and R8 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(iii) formula (1C):
wherein, R9, R11, and R13 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R10, R12 and R14 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
(iv) formula (1D):
wherein, R17-R20 and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21, R22 and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl
(v) formula (1D):
wherein, R17-R20, R23, and R24 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
wherein, R21 and R22 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
or
(vi) formula (1D):
wherein, R17, R19, R20, and R23 are independently selected from the group consising of hydrogen;
alkyl;
allyl;
methyl;
ethyl;
n-propyl;
isopropyl;
n-butyl;
isobutyl;
n-butylamine;
sec-butyl;
tert-butyl;
pentyl;
hexyl;
isopentyl;
aryl;
heteroaryl;
furanyl;
indolyl;
thiophenyl;
thiazolyl;
imidazolyl;
isoxazoyl;
oxazoyl;
piperonyl;
pyrazoyl;
pyrrolyl;
pyrazinyl;
pyridyl;
pyrimidyl;
pyrimidinyl;
purinyl;
cinnolinyl;
benzofuranyl;
benzothienyl;
benzotriazolyl;
benzoxazolyl;
quinoline;
isoxazolyl;
isoquinoline cycloalkyl;
alkenyl;
cycloalkenyl;
phenyl;
pyridyl;
methoxyethyl;
(R)-methylbenzyl;
C1-6 alkyl unsubstituted or substituted with NH2, OH, or SH;
C2-6 alkynyl unsubstituted or substituted with NH2, OH, or SH;
lysyl;
carboxyl;
and hydroxyl group;
and
R18, R21, and R24 are independently selected from the group consisting of C0-6 alkylaryl;
C0-6 alkylheteroaryl;
C1-6 alkyl substituted with a group selected from OH, SH, a halogen, OR15, COOR15, NR15 (wherein R15 is selected from the group consisting of H or C1-6 alkyl or C1-6 alkynl) or R16 (wherein R16 is selected from the group consisting of H or C1-6 alkynl);
OC1-6 alkyl;
C2-6 alkenyl;
C2-6 alkynyl;
C2-6 alkenyl;
and C2-6 alkynyl;
and
wherein Z is coupling group;
L is an optional linker moiety, M is a substrate or support;
and m, n, o, and/or p is 0-6;
and
(b) detecting antibodies bound to said peptoid.

371 more elements

Facts

Application

12/791,389Filed 1 Jun 2010

Priority

2 Jun 2009

Published

2 Dec 2010

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

G01N 33/6896
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A61P 25/28
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G01N 33/564
Immunoassay; Biospecific binding assay; Materials therefor: for pre-existing immune complex or autoimmune disease , i.e. systemic lupus…
G01N 33/6845
General methods of protein analysis not limited to specific proteins or families of proteins: methods of identifying protein-protein interactions…