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AssigneeNovagen Holding Corporation
InventorsHaitao Wang, Chunsheng Mao, Jizhi Li, Ling Wang, Yong Du, Longbin Liu, Jing Xu, Rui Zhang
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This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.
An isolated polynucleotide encoding a protein having human interferon-like biological activities, wherein said polynucleotide is selected from the group consisting of polynucleotides each comprising a nucleotide sequence at least 95% identical to SEQ ID No:
A non-naturally occurring protein exhibiting human interferon-like biological activities, wherein said protein is selected from the group consisting of proteins each comprising an amino acid sequence at least 89% identical to SEQ ID No:
A non-naturally occurring protein comprising a sequence which differs in 0 to 19 amino acids from SEQ ID No:
A non-naturally occurring protein exhibiting human interferon-like biological activities, wherein said protein has an amino acid sequence at least 95% identical to SEQ ID No:
A protein having the amino acid sequence of SEQ ID No:
An isolated polynucleotide encoding a protein having human interferon-like biological activities, wherein said polynucleotide is selected from the group consisting of polynucleotides each comprising a nucleotide sequence at least 97% identical to SEQ ID No:
A protein exhibiting human interferon-like biological activities, wherein said protein is selected from the group consisting of proteins each comprising an amino acid sequence at least 95% identical to SEQ ID No:
A protein comprising a sequence which differs in 0 to 8 amino acids from SEQ ID No:
Dependencies are inferred from the claim text.