Methods of Treating Chronic Neurogenic Inflammation Using Interleukin Retargeted Endopepidases

A method of treating chronic neurogenic inflammation in a mammal, the method comprising the step of administering to the mammal in need thereof a therapeutically effective amount of a composition including a TVEMP comprising a retargeted peptide binding domain, a Clostridial toxin translocation domain, a Clostridial toxin enzymatic domain, and an exogenous protease cleavage site, wherein the retargeted peptide binding domain is an interleukin (IL) peptide binding domain, a vascular endothelial growth factor (VEGF) peptide binding domain, an insulin-like growth factor (IGF) peptide binding domain, or an epidermal growth factor (EGF) peptide binding domain, and wherein administration of the composition reduces the release of an inflammation inducing molecule, thereby reducing a symptom associated with chronic neurogenic inflammation.

Use of a TVEMP in the manufacturing a medicament for treating chronic neurogenic inflammation in a mammal in need thereof, wherein the TVEMP comprising a retargeted peptide binding domain, a Clostridial toxin translocation domain and a Clostridial toxin enzymatic domain, and an exogenous protease cleavage site, wherein the retargeted peptide binding domain is an interleukin (IL) peptide binding domain, a vascular endothelial growth factor (VEGF) peptide binding domain, an insulin-like growth factor (IGF) peptide binding domain, or an epidermal growth factor (EGF) peptide binding domain, and wherein administration of a therapeutically effective amount of the medicament to the mammal reduces the release of an inflammation inducing molecule, thereby reducing a symptom associated with chronic neurogenic inflammation.

Use of a TVEMP in the treatment of chronic neurogenic inflammation in a mammal in need thereof, the use comprising the step of administering to the mammal a therapeutically effective amount of the TVEMP, wherein the TVEMP comprising a retargeted peptide binding domain, a Clostridial toxin translocation domain, a Clostridial toxin enzymatic domain, and an exogenous protease cleavage site, wherein the retargeted peptide binding domain is an interleukin (IL) peptide binding domain, a vascular endothelial growth factor (VEGF) peptide binding domain, an insulin-like growth factor (IGF) peptide binding domain, or an epidermal growth factor (EGF) peptide binding domain, and wherein administration of the TVEMP reduces the release of an inflammation inducing molecule, thereby reducing a symptom associated with chronic neurogenic inflammation.

A method of treating chronic neurogenic inflammation in a mammal, the method comprising the step of administering to the mammal in need thereof a therapeutically effective amount of a composition including a TVEMP comprising a retargeted peptide binding domain, a Clostridial toxin translocation domain and a Clostridial toxin enzymatic domain,

• wherein the retargeted peptide binding domain is an interleukin (IL) peptide binding domain, a vascular endothelial growth factor (VEGF) peptide binding domain, an insulin-like growth factor (IGF) peptide binding domain, or an epidermal growth factor (EGF) peptide binding domain, and
• wherein administration of the composition reduces a symptom associated with chronic neurogenic inflammation, thereby treating chronic neurogenic inflammation.