Methods of Treating Urogenital-Neurological Disorders Using Interleukin Retargeted Endopepidases

A method of treating urogenital-neurological disorder in a mammal, the method comprising the step of administering to the mammal in need thereof a therapeutically effective amount of a composition including a TVEMP comprising a retargeted peptide binding domain, a Clostridial toxin translocation domain, a Clostridial toxin enzymatic domain, and an exogenous protease cleavage site, wherein the retargeted peptide binding domain is an interleukin (IL) peptide binding domain, a vascular endothelial growth factor (VEGF) peptide binding domain, an insulin-like growth factor (IGF) peptide binding domain, or an epidermal growth factor (EGF) peptide binding domain, and wherein administration of the composition reduces a symptom of the urogenital-neurological disorder, thereby treating the mammal.

Use of a TVEMP in the manufacturing a medicament for treating urogenital-neurological disorder in a mammal in need thereof, wherein the TVEMP comprising a retargeted peptide binding domain, a Clostridial toxin translocation domain and a Clostridial toxin enzymatic domain, wherein the retargeted peptide binding domain is an interleukin (IL) peptide binding domain, a vascular endothelial growth factor (VEGF) peptide binding domain, an insulin-like growth factor (IGF) peptide binding domain, or an epidermal growth factor (EGF) peptide binding domain, and wherein administration of a therapeutically effective amount of the medicament to the mammal reduces a symptom of the urogenital-neurological disorder, thereby treating the mammal.

A use of a TVEMP in the manufacturing a medicament for treating urogenital-neurological disorder in a mammal in need thereof, the use comprising the step of administering to the mammal a therapeutically effective amount of the composition, wherein the TVEMP comprising a retargeted peptide binding domain, a Clostridial toxin translocation domain, a Clostridial toxin enzymatic domain, and an exogenous protease cleavage site, wherein the retargeted peptide binding domain is an interleukin (IL) peptide binding domain, a vascular endothelial growth factor (VEGF) peptide binding domain, an insulin-like growth factor (IGF) peptide binding domain, or an epidermal growth factor (EGF) peptide binding domain, and wherein administration of the composition reduces a symptom of the urogenital-neurological disorder, thereby treating the mammal.