Process for preparation of cyclodextrin oligomers or polymers, products obtained and uses
AssigneeBiocydex
InventorsFrederic Turpin, Carole Brigand, Yves Cenatiempo, EI Mustapha Belgsir
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Abstract
A process for the preparation of cyclodextrin oligomers or polymers, whereby the cyclodextrin molecules are coupled to one another covalently via a spacer arm, based on a coupling reaction between an alkyne and an azide producing the formation of an aromatic heterocyclic bridge between the coupled units. Also described are the cyclodextrin oligomers or polymers that are obtained and their uses.
Claims14
Process for preparation of cyclodextrin oligomers or polymers, whereby the cyclodextrin molecules are coupled to one another covalently via a spacer arm, characterized in that it comprises at least the following stages:
- Integration of at least one alkyne group on each cyclodextrin so as to obtain acetylene cyclodextrins and at least two azide groups on each spacer arm, and
- Creation of bonds between the spacer arm(s) and the cyclodextrins in the form of 1,2,3-triazole cycles by coupling reaction between the alkynes and the azides.
Process for preparation of cyclodextrin oligomers or polymers, whereby the cyclodextrin molecules are coupled to one another covalently via a spacer arm, wherein it comprises at least the following stages:
- Integration of at least one azide group on each cyclodextrin so as to obtain azide cyclodextrins and at least two alkyne groups on each spacer arm, and
- Creation of bonds between the spacer arm(s) and the cyclodextrins in the form of 1,2,3-triazole cycles by coupling reaction between the alkynes and the azides.
Dependencies are inferred from the claim text.