NMR Diagnostics by Means of a Plastic Sample Container
AssigneeT2 Biosystems, Inc.
InventorsThomas J. Lowery, JR., Robert Palazzolo
Life of this patent
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Abstract
Sample containers and methods for employing the same in in-vitro nuclear magnetic resonance measurements are provided. The sample containers are made of a material that comprises one or more polymeric materials.
Claims20
A method for obtaining a nuclear magnetic resonance relaxation parameter of a sample, the method comprising:
- (a) applying a radiofrequency pulse sequence in the presence of a magnetic field to the sample and a sample container containing the sample, resulting in an NMR signal associated with the sample and an NMR signal associated with the sample container, wherein the sample container comprises a polymeric material;
- (b) acquiring part or all of the resulting NMR signals to obtain raw data;
- and
- (c) processing the resulting NMR signals to obtain the nuclear magnetic resonance parameter of the sample;
- and
- (d) reducing, partly or completely, contribution of the NMR signal associated with the sample container to the nuclear magnetic resonance parameter of the sample;
- wherein the nuclear magnetic resonance relaxation parameter is a time domain signal.
9-49. (canceled)
A method for obtaining a nuclear magnetic resonance relaxation parameter of one or more samples in-vitro using a nuclear magnetic resonance device, the method comprising:
- containing the one or more samples in a sample container within the nuclear magnetic resonance device, the sample container being made of a material that comprises one or more polymeric materials, wherein the nuclear magnetic resonance relaxation parameter is a time domain signal.
52-68. (canceled)
A method for obtaining T2 of one or more samples using a nuclear magnetic resonance device, wherein the nuclear magnetic resonance device comprises one or more radiofrequency coils with an associated detection volume and one or more magnets, the method comprising:
- positioning a sample container made of a material that comprises one or more polymeric materials within the detection volume of the one or more radiofrequency coils;
- applying a magnetic field provided by the one or more magnets to the sample container;
- applying a radiofrequency pulse sequence in the presence of the magnetic field to the sample container and one or more samples, resulting in NMR signals associated with the one or more samples and NMR signals associated with the sample container;
- acquiring the NMR signals to obtain raw data;
- and processing the raw data to obtain T2 of the one or more samples in the sample container.
Dependencies are inferred from the claim text.