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US 2010/0301857 A1Published application
Multiplex imaging systems, devices, methods, and compositions including ferromagnetic structures
AssigneeSearete LLC, a limited liability corporation of the State of Delaware
InventorsRoderick A. Hyde, Jordin T. Kare, Wayne R. Kindsvogel
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Abstract
Multiplex imaging systems, devices, methods, and compositions are provided. A nuclear magnetic resonance imaging composition includes, but is not limited to, a plurality of ferromagnetic microstructures configured to generate a time-invariant magnetic field within at least a portion of one or more internal surface-defined voids.
Claims20
A multiplex nuclear magnetic resonance imaging composition, comprising
- a plurality of ferromagnetic microstructure sets,
- each ferromagnetic microstructure set comprising one or more ferromagnetic microstructures configured to include an accessible internal void and configured to generate a characteristic time-invariant magnetic field within the accessible internal void;
- and
- at least one of the ferromagnetic microstructure sets having a different characteristic time-invariant magnetic field from another of the plurality of ferromagnetic microstructure sets.
1 more element
A multiplex imaging method, comprising
- affecting at least one of a proton transverse magnetic relaxation time or a proton longitudinal magnetic relaxation time associated with a biological sample by providing a plurality of ferromagnetic microstructure sets,
- each ferromagnetic microstructure set comprising one or more ferromagnetic microstructures configured to include an accessible internal void and configured to generate a characteristic time-invariant magnetic field within the accessible internal void;
- and
- one or more of the ferromagnetic microstructure sets having a different characteristic time-invariant magnetic field.
1 more element
A method of multiplex interrogation of a biological sample, comprising:
- detecting nuclear magnetic resonance information generated by in vivo nuclear magnetic resonance detectable nuclei exposed to one or more internal-surface-defined voids of a plurality of different ferromagnetic microstructures configured to generate a static magnetic flux density within at least a portion of the one or more internal-surface-defined voids and configured to affect a magnetic resonance relaxation process associated with the in vivo nuclear magnetic resonance detectable nuclei while the in vivo nuclear magnetic resonance detectable nuclei are received in at least one of the one or more internal-surface-defined voids.
Dependencies are inferred from the claim text.