Method of diagnostic heparic disease by sugar chain analysis
OwnerShin-Ichiro Nishimura, Satoru Todoinventors
Life of this patent
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Abstract
It is intended to provide a novel diagnosis method for a hepatic disease, in particular, HCC. A serum sugar chain usable as a novel biomarker is provided by analyzing the relationship between the quantitative expression profiles of sugar chains in the serum and individual disease conditions and thus finding a sugar chain showing a change with the progression of a hepatic disease.
Claims15
A method for diagnosing a hepatic disease using an expression level of one or more sugar chains as an index, wherein the sugar chains are selected from a group consisting of G2, G8, G9, G10, G11, G12, G14, G15, G16, G17, G18, G20, G21, G23, G26, G27, G30, G31, G33, G37, G45 and G56.
A method for diagnosing hepatocellular carcinoma using an expression level of one or more sugar chains as an index, wherein the sugar chains are selected from a group consisting of G2, G9, G12, G15, G17, G21, G27, G30, G37, G45 and G56.
A method for predicting prognosis of hepatocellular carcinoma using an expression level of one or more sugar chains as an index, wherein the sugar chains are selected from a group consisting of G2, G20, G45 and G56.
A method for diagnosing hepatocellular carcinoma in early stage using an expression level of the sugar chains G20 and/or G26 as an index.
A method for diagnosing hepatopathy using an expression level of one or more sugar chains as an index, wherein the sugar chains are selected from a group consisting of G8, G10, G11, G14, G16, G18, G23, G31 and G33.
A method for diagnosing a benign hepatic disease using an expression level of one or more sugar chains as an index, wherein the sugar chains are selected from a group consisting of G8, G10, G11, G14, G16, G18, G23, G31 and G33.
Use of one or more sugar chains as a marker for a hepatic disease, wherein the sugar chains are selected from a group consisting of G2, G8, G9, G10, G11, G12, G14, G15, G16, G17, G18, G20, G21, G23, G26, G27, G30, G31, G33, G37, G45 and G56.
Use of one or more sugar chains as a marker for hepatocellular carcinoma, wherein the sugar chains are selected from a group consisting of G2, G9, G12, G15, G17, G21, G27, G30, G37, G45 and G56.
Use of one or more sugar chains as a marker for predicting prognosis of hepatocellular carcinoma, wherein the sugar chains are selected from a group consisting of G2, G20, G45 and G56.
Use of the sugar chains G20 and/or G26 as a marker for diagnosing hepatocellular carcinoma in early stage.
Use of one or more sugar chains as a marker for hepatopathy, wherein the sugar chains are selected from a group consisting of G8, G10, G11, G14, G16, G18, G23, G31 and G33.
Use of one or more sugar chains as a marker for a benign hepatic disease, wherein the sugar chains are selected from a group consisting of G8, G10, G11, G14, G16, G18, G23, G31 and G33.
Dependencies are inferred from the claim text.