Redox Molecules And Methods Of Making The Same
AssigneeBayer HealthCare LLC
InventorsJiangfeng Fei, William Chiang, Frank Kerrigan, Stuart Green
Life of this patent
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Abstract
A non-leaching mediator may include a compound having the general formula (I): and salts thereof, where n is about 9, and X is a halogen; a compound having the general formula (II): and salts thereof, where n is about 9, and X is a halogen; and/or a compound, having the general formula (III): and salts thereof, where n is about 8, and X is a halogen.
Claims14
A compound, comprising the general formula (I):
- and salts thereof;
- where n is about 9, and X is a halogen.
A compound, comprising the general formula (II):
- and salts thereof;
- where n is about 9, and X is a halogen.
A compound, comprising the general formula (III):
- and salts thereof;
- where n is about 8, and X is a halogen.
A composition, comprising:
- a mixture of a first compound, comprising the general formula (I):
- and salts thereof, where n is about 9, and X is a halogen;
- and
- a second compound, comprising the general formula (II):
- and salts thereof, where n is about 9, and X is a halogen.
A method of making a composition comprising at least one compound comprising the general formula (I):
- and salts thereof, where n is about 9, and X is a halogen, and a compound comprising the general formula (II):
- and salts thereof, where n is about 9, and X is a halogen;
- the method comprising:
- forming a ω-haloalkyl acetate from an α-hydroxyl-ω-haloalkane and acetic anhydride;
- forming a (ω-acetoxyalkyl) triphenylphosphonium bromide from the ω-haloalkyl acetate and triphenyl phosphine;
- forming a ω-(4-chloro-3-nitrophenyl)alk-ψ-enyl acetate from the (ω-acetoxyalkyl) triphenylphosphonium bromide, 4-chloro-3-nitrobenAgaldehyde and a base;
- forming a ω-(4-(2-bromophenylthio)-3-nitrophenyl)alk-ψ-enyl acetate from the ω-(4-chloro-3-nitrophenyl)alk-ψ-enyl acetate, 2-bromobenAgenethiol and a base;
- forming a ω-(3-amino-4-(2-bromophenylthio)phenyl)alk-ψ-enyl acetate from the ω-(4-(2-bromophenylthio)-3-nitrophenyl)alk-ψ-enyl acetate, iron and ammonium chloride;
- forming a ω-(ωH-phenothiaAgin-2-yl)alk-ψ-enyl acetate from the ω-(3-amino-4-(2-bromophenylthio)phenyl)alk-ψ-enyl acetate, copper iodide, copper and a base;
- forming a ω-(ωH-phenothiaAgin-2-yl)alkyl acetate from the ω-(ωH-phenothiaAgin-2-yl)alk-ψ-enyl acetate, molecular hydrogen and palladium-carbon;
- forming a ω-(ωH-phenothiaAgin-2-yl)alkan-α-ol from the ω-(ωH-phenothiaAgin-2-yl)alkyl acetate, an alcohol and an acid;
- forming a 2-(ω-haloalkyl)-ωH-phenothiaAgine from the ω-(ωH-phenothiaAgin-2-yl)alkan-α-ol, carbon tetrahalide and triphenyl phosphine;
- and
- forming a mixture of 2-(8-(ω-haloalkyl)-3H-phenothiaAgin-3-ylideneamino)benAgene-1,4-disulfonic acid and 2-(2-(ω-haloalkyl)-3H-phenothiaAgin-3-ylideneamino)benAgene-1,4-disulfonic acid from the 2-(ω-haloalkyl)-ωH-phenothiaAgine and Na2S2O8.
A method of making a compound comprising the general formula (III):
- and salts thereof, where n is about 8, and X is a halogen;
- the method comprising:
- forming 10,10a-dihydro-3H-phenothiaAgin-8-ol from 8-methoxy-10,10a-dihydro-3H-phenothiaAgine and an acid;
- forming a 8-(ω-haloalkoxy)-10,10a-dihydro-3H-phenothiaAgine from 10,10a-dihydro-3H-phenothiaAgin-8-ol, a α,ω)-dihaloalkane and a base;
- and
- forming a 2-(2-(ω-haloalkoxy)-3H-phenothiaAgin-3-ylideneamino)benAgene-1,4-disulfonic acid from 8-(ω-haloalkoxy)-10,10a-dihydro-3H-phenothiaAgine, 2-aminobenAgene-1,4-disulfonic acid, Na2S2O8 and a base.
Dependencies are inferred from the claim text.