Peripheral and neural inflammatory crosstalk
AssigneeUniversity of Rochester
InventorsStephanos Kyrkanides, M. Kerry O'Banion, Ross H. Tallents
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Abstract
Disclosed are compositions and methods for the study and treatment of inflammatory disease, neurological disorders, bone disease, pain, and methods of making and using thereof.
Claims41
A method for treating or preventing peripheral inflammation in a subject, comprising administering an inflammation inhibitor to the central nervous system of the subject.
A method for treating or preventing bone disease in a subject, comprising administering an inflammation inhibitor to the central nervous system of the subject.
A method for treating or preventing chronic pain in a subject, comprising administering an inflammation inhibitor to the central nervous system of the subject.
A method for treating or preventing a brain disorder in a subject, comprising administering an inflammation inhibitor to a site of peripheral inflammation in the subject.
The method of claim 29, wherein the vector comprises a nucleic acid that encodes a polypeptide that inhibits the binding of the mediator of inflammation to its receptor.
Dependencies are inferred from the claim text.