Cytomegalovirus Vaccines and Methods of Production
AssigneeThe Trustees of Princeton University
InventorsThomas Shenk, Dai Wang
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Abstract
Methods of increasing diversity in cytomegalovirus vaccines through the selection of cell type in which the virus is propagated, and the use of cytomegalovirus produced by those methods in the development of vaccine compositions, are disclosed. Vaccine compositions comprising CMV isolated from epithelial cells are also disclosed.
Claims20
A method of making a cytomegalovirus (CMV) vaccine comprising:
- a) propagating strains or isolates of CMV in cultured cells of a selected cell type, thereby producing a cell type-conditioned CMV;
- and
- b) producing a CMV vaccine from the cell type-conditioned CMV.
A kit comprising a container in which is contained:
- a) one or CMV strains or clinical isolates;
- b) cultured cells of one or more selected cell types;
- and
- c) instructions for using the cultured cells and the CMV strains or isolates to produce cell type-conditioned CMV for use in a CMV vaccine.
A vaccine composition comprising a cytomegalovirus (CMV) population or virion components thereof, admixed with a suitable pharmaceutical carrier or adjuvant, wherein the CMV population is isolated from an epithelial cell culture.
A method of immunizing an individual against CMV, comprising administering to the individual a CMV vaccine composition comprising a cytomegalovirus (CMV) population or virion components thereof, admixed with a suitable pharmaceutical carrier or adjuvant, wherein the CMV population is isolated from an epithelial cell culture.
Dependencies are inferred from the claim text.