Factor involved in latent infection with herpesvirus, and use thereof
AssigneesVirus Ikagaku Kenkyusho Inc., Japan Tobacco Inc.
InventorsKazuhiro Kondo, Nobuyuki Kobayashi
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Abstract
Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.
Claims23
A gene being:
- (a) a gene encoding a protein having the amino acid sequence shown in SEQ ID NO:
- 1;
- (b) a gene encoding a protein having an amino acid sequence with a substitution, deletion, insertion, and/or addition of one or several amino acids in the amino acid sequence shown in SEQ ID NO:
- 1, the protein having activity of increasing an intracellular calcium concentration;
- (c) a gene comprising an open reading frame region having the nucleotide sequence shown in SEQ ID NO:
- 2;
- or
- (d) a gene encoding a protein that hybridizes under stringent hybridization conditions with DNA having a nucleotide sequence complementary to DNA having the nucleotide sequence shown in SEQ ID NO:
- 2, the protein having activity of increasing an intracellular calcium concentration.
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Dependencies are inferred from the claim text.