Ribozyme to cleave coronavirus gene
OwnerNoboru Fukuda, Takahiro Ueno +2inventors
InventorsNoboru Fukuda, Takahiro Ueno, Akiko Fukushima, Kazumichi Kuroda
Life of this patent
Estimating the term…
Abstract
Provided is a ribozyme to cleave a coronavirus gene and a therapeutic agent for a coronavirus infectious disease. A common base sequence in coronaviruses such as SARS-CoV and MHV was searched to design a ribozyme including a base sequence complementary thereto. Moreover, a therapeutic agent for a coronavirus infectious disease including such ribozyme was obtained.
Claims10
A ribozyme, which cleaves a gene of a virus belonging to the coronavirus family.
A ribozyme having a sequence of SEQ ID NO:
- 1 in SEQUENCE LISTING.
A method of designing a ribozyme, comprising selecting a specific base sequence of a coronavirus, wherein the ribozyme includes a sequence complementary thereto.
A method of designing a ribozyme, comprising selecting a specific base sequence by combining at least two of the following steps 1) to 3):
- 1) selecting a base sequence in a conserved region of a coronavirus gene;
- 2) selecting a base sequence in a common region of a coronavirus gene;
- 3) selecting a base sequence that includes a loop structure of a coronavirus gene.
Dependencies are inferred from the claim text.