Milk Protein Hydrolyzates with Reduced Immunogenic Potential
AssigneeDanisco A/S
InventorsManoj Kumar, David Wong
Life of this patent
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Abstract
Hydrolyzate compositions comprising at least one milk protein or whey hydrolyzed with at least one proteolytic enzyme are provided. The hydrolyzates reduce the immunogenicity of the milk or whey protein in a subject predisposed to having an immune reaction to the protein. Methods for making the compositions are also provided, as food products and nonfood products comprising the compositions.
Claims23
A hydrolyzate comprising at least one milk protein hydrolyzed with at least one proteolytic enzyme that cleaves preferentially at a glutamic acid or aspartic acid residue and that cleaves one or more immunological determinants present in the protein, the hydrolyzate comprising at least a beta lactoglobulin hydrolyzed in the region between amino acids 55-98, the hydrolyzate having reduced immunogenicity in a subject predisposed to having an immune reaction to the protein.
A hydrolyzate comprising at least one milk protein hydrolyzed with at least one proteolytic enzyme that cleaves preferentially at a glutamic acid or aspartic acid residue, wherein the proteolytic enzyme is the endopeptidase UniProtKB/Swiss-Prot Primary Accession Number P39790, the hydrolyzate having reduced immunogenicity in a subject predisposed to having an immune reaction to the protein.
A food ingredient comprising a whey protein hydrolyzate enriched in one or more of the peptides AQSAPLRVYVE (SEQ ID NO:
- 1), ILLQKWE (SEQ ID NO:
- 2), KTKIP A VFKID (SEQ ID NO:
- 3), or KTKIP A VFKID ALNE (SEQ ID NO:
- 4), having reduced immunogenicity in a subject predisposed to having an immune reaction to one or more whey proteins.
A manufactured food product comprising a whey protein hydrolyzate enriched in one or more of the peptides AQSAPLRVYVE (SEQ ID NO:
- 1), ILLQKWE (SEQ ID NO:
- 2), KTKIPAVFKID (SEQ ID NO:
- 3), or KTKIP AVFKID ALNE (SEQ ID NO:
- 4), having reduced immunogenicity in a subject predisposed to having an immune reaction to one or more whey proteins.
A non-food product that comprises a hydrolyzate comprising at least one milk protein hydrolyzed with at least one proteolytic enzyme that cleaves preferentially at a glutamic acid or aspartic acid residue the hydrolyzate having reduced immunogenicity in a subject predisposed to having an immune reaction to the protein.
23-25. (canceled)
Dependencies are inferred from the claim text.