System for targeted delivery of therapeutic agents
AssigneesMassachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
InventorsOmid C. FAROKHZAD, Jianjun CHENG, Benjamin A. TEPLY, Robert S. LANGER, Stephen E. ZALE
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Abstract
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.
Claims80
A targeted particle, comprising:
- a particle;
- a targeting moiety;
- and
- a therapeutic agent;
- wherein the particle comprises a polymeric matrix, wherein the polymeric matrix comprises a polyester, and wherein the targeting moiety targets prostate cancer cells.
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A method of preparing a targeted particle comprising:
- providing a therapeutic agent;
- providing a polymer;
- providing a targeting moiety;
- mixing the polymer with the therapeutic agent to prepare particles;
- and
- associating the particles with the targeting moiety;
- wherein the polymer comprises a polyester, and wherein the targeting moiety targets prostate cancer cells.
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A targeted particle, comprising:
- a particle;
- a targeting moiety;
- and
- a therapeutic agent;
- wherein the particle comprises a polymeric matrix, wherein the polymeric matrix comprises a polyester, wherein the targeting moiety targets prostate cancer cells, and wherein the targeting moiety is a urea-based inhibitor.
Dependencies are inferred from the claim text.