Prostacyclin derivatives
AssigneeConcert Pharmaceuticals, Inc.
InventorRoger D. Tung
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Abstract
This invention relates to novel prostacyclin derivatives, their acceptable acid addition salts, solvates, hydrates and polymorphs thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by prostacyclin, and in particular those diseases and conditions beneficially treated by dilators of systemic and pulmonary arterial vascular beds or by platelet aggregation inhibitors.
Claims27
A compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- each Y is independently selected from hydrogen or deuterium;
- each Z is independently selected from hydrogen, deuterium or fluorine;
- and
- at least one Y or Z is deuterium.
(canceled)
(canceled)
(canceled)
A compound of formula II:
- or a pharmaceutically acceptable salt thereof, wherein:
- each Y is independently selected from hydrogen or deuterium;
- each Z is independently selected from hydrogen and deuterium;
- and
- at least one Y3 is deuterium.
(canceled)
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A compound selected from:
- or a pharmaceutically acceptable salt thereof.
23-28. (canceled)
32-35. (canceled)
Dependencies are inferred from the claim text.