P2x4 receptor antagonist

A compound having the following formula (I) or a pharmacologically acceptable salt thereof:

• in which
• X represents O, S or NH;
• Y represents N or NR6 in which R6 is hydrogen or an alkyl group having 1-8 carbon atoms;
• R1 represents hydrogen, an alkyl group having 1-8 carbon atoms, an alkenyl group having 2-8 carbon atoms, an alkyl group having 1-8 carbon atoms which has 1-3 halogen substituents, or an alkyl group having a phenyl substituent;
• R2 represents an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkyl group having 1-8 carbon atoms which has 1-3 halogen substituents, hydroxyl, nitro, amino, carboxyl, tetrazolyl, or cyano;
• R3 represents hydrogen, an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkyl group having 1-8 carbon atoms which has 1-3 halogen substituents, a halogen atom, hydroxyl, nitro, amino, carboxyl, tetrazolyl, or cyano;
• each of R4 and R5 independently represents hydrogen, an alkyl group having 1-8 carbon atoms, or an alkyl group having 1-8 carbon atoms which has 1-3 halogen substituents;
• m is 1 or 2;
• and
• the double line consisting of a solid line and a broken line represents a double bond in the case that Y is N and a single bond in the case that Y is NR6.