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US 2010/0251394 A1Published application
Treatment and prevention of ischemic brain injury
AssigneeThe Johns Hopkins University
InventorSylvain Doré
Life of this patent
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Abstract
The invention provides methods of identifying agents for treating and preventing ischemic brain injury.
Claims6
A method for identifying an agent that may be useful in the treatment or prevention of ischemic brain injury, comprising:
- contacting a lipocalin-type prostaglandin synthetase (L-PGDS) with a test compound;
- determining whether the test compound increases enzymatic activity of the L-PGDS molecule;
- and
- determining whether the test compound prevents or decreases a symptom of ischemic brain injury in an animal model.
1 more element
A method for identifying an agent that may be useful in the treatment or prevention of ischemic brain injury, comprising:
- contacting a mammalian cell which expresses L-PGDS with a test compound;
- determining whether the test compound increases expression of the L-PGDS;
- and
- determining whether the test compound prevents or decreases a symptom of ischemic brain injury in an animal model.
1 more element
Dependencies are inferred from the claim text.