Method of Electrogenically Controlling Pump Molecules
AssigneeUniversity of South Florida
InventorWei Chen
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Abstract
Activation of electrogenic pump molecules can be realized by a dynamic entrainment procedure which includes two steps: synchronization of individual pump molecules to work at the same pumping pace, and gradual modulation of the synchronization frequency. Na/K pump molecules were used as an example in a physiological operating mode by applying the concept of an electronic synchrotron to the biological system. It was shown that individual Na/K pump molecules can be synchronized by a well designed oscillating electric field. The synchronized pump currents show separated inward and outward pump currents and a magnitude ratio of 3:2 reflecting stoichiometric number of the pump molecules.
Claims27
A method of controlling the cycle of a plurality of carrier-mediated ion transporters comprising the steps of:
- applying an oscillating electric field at a predetermined synchronization frequency wherein the frequency is substantially equal to the ion transporters initial natural turnover rate;
- and
- incrementally adjusting the synchronization frequency to control the cycle.
A method of controlling the cycle of a plurality of Na/K pump molecules comprising the steps of:
- applying an oscillating electric field at a predetermined synchronization frequency wherein the frequency is substantially equal to the pump molecules' initial natural turnover rate and;
- incrementally adjusting the synchronization frequency to control the cycle.
A method of treating a disease in a subject characterized by a deregulation of Na/K pump molecule function comprising the steps of:
- applying an oscillating electric field at a predetermined synchronization frequency wherein the frequency is substantially equal to the pump molecules' initial natural turnover rate and;
- incrementally adjusting the synchronization frequency to control the cycle.
Dependencies are inferred from the claim text.