Drug delivery system for accelerated subcutaneous absorption
OwnerJeffrey A. Kleininventor
Life of this patent
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Abstract
A method for accelerating subcutaneous absorption of a fluid or drug into the systemic circulation of a specific targeted tissue. A first drug operative to produce local capillary vasodilatation and/or increase the rate of bulk flow of solution through the interstitial space is mixed with a fluid. The fluid may contain a crystalloid solution or a dilute solution of a pharmacologic drug required for a routine or emergency therapeutic treatment for a patient. The first drug is substantially non-toxic to the patient. The fluid mixed with the first drug is then delivered subcutaneously or into deeper tissues of the patient, by use of a hyperdermic needle or infiltration cannula. As the capillaries are dilated, the fluid is efficiently absorbed and circulated systemically.
Claims19
A drug delivery method for increasing a rate of systemic absorption of a solution, the steps consisting essentially of:
- a) dissolving a first drug at a substantially non-toxic concentration with a fluid solvent, wherein the first drug is a vasodilator to produce local capillary vasodilation;
- b) subcutaneously or intramuscularly applying the fluid containing the first drug to a patient.
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A method of increasing absorption rate of a therapeutic drug, comprising:
- applying a first solution in a first level under skin of a patient, wherein the first solution contains a therapeutic drug for treating subcutaneous tissue of the patient;
- and
- applying a second solution in a second level under the skin of the patient, wherein the second solution contains a vasoconstrictive drug;
- wherein
- the second level is deeper than the first level to serve as a buffer for preventing or delaying absorption of the therapeutic drug into deep vascular tissue.
A method of increasing absorption rate of a therapeutic drug, comprising:
- applying a first solution in a first level under the skin of a patient, wherein the first solution contains a therapeutic drug for treating the skin of the patient;
- and
- applying a second solution in a second level under the skin of the patient, wherein the second solution contains a vasoconstrictive drug only;
- wherein
- the first level is deeper than the second level to serve as a buffer for preventing or delaying absorption of the therapeutic drug into superficial region of the skin.
A method of field treating an injured person at a remote area, the method comprising the steps of:
- diagnosing the injured person while at the remote area;
- providing a first drug at a substantially non-toxic concentration with a fluid solvent at room temperature, the first drug being a vasodilator to produce local capillary vasodilation;
- while at the remote area, subcutaneously or intramuscularly applying the fluid solvent containing the first drug to the injured person.
Dependencies are inferred from the claim text.