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US 2010/0249459 A1Published application
Formoterol Tartrate Process and Polymorph
AssigneeSepracor Inc.
InventorsGerald J. Tanoury, Chris H. Senanayake, Donald W. Kessler
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Abstract
A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
Claims3
A process for preparing (R,R)-formoterol L-tartrate polymorph A comprising:
- converting (R,R)-formoterol L-tartrate polymorph B to (R,R)-formoterol L-tartrate polymorph C in a solvent system comprising isopropyl alcohol, water, and at least 13% toluene, wherein the solvent system is maintained at between 40° C. and 55° C., and crystallizing (R,R)-formoterol L-tartrate polymorph C to prepare (R,R)-formoterol L-tartrate polymorph A.
Dependencies are inferred from the claim text.