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US 2010/0249435 A1Published application
Polymorphs of enantiopure erdosteine
AssigneeEdmond Pharma s.r.l.
InventorsPier Andrea Gatti, Matteo Zacche', Massimo Nicola
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Abstract
The present invention provides novel crystalline polymorphs of enantiopure Erdosteine, referred to as Form I and Form II, and processes for the preparation thereof.
Claims10
Crystalline (R) or (S) Erdosteine Form (I), which shows:
- an X-ray powder diffraction pattern with peaks at about 17.0, 20.1, 22.8, 23.4, 27.3, 28.0, 29.1, 30.6, 33.2±0.2 degrees two-theta;
- an infrared absorption spectrum with peaks at about 1740, 1692, 1683, 1607 and 1576 cm-1;
- and
- a melting point at about 112-134° C., with onset at 123° C. and with a DSC thermogram.
1 more element
Crystalline (R) or (S) Erdosteine Form (II), which shows:
- an X-ray powder diffraction pattern with peaks at about 18.3, 24.7, 28.9, 31.3, 32.3, 32.7, 36.0, 36.3, 37.2±0.2 degrees two-theta;
- an infrared absorption spectrum with peaks at about 1708, 1692, 1644, 1538 and 1189 cm-1;
- and
- a melting point at about 103-142° C. (onset at 126° C.), with a DSC thermogram.
1 more element
Dependencies are inferred from the claim text.