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US 2010/0249428 A1Published application
Process for the preparation of propionic acid derivatives
AssigneeHoffman-La Roche Inc.
InventorsKurt Puentener, Michelangelo Scalone
Life of this patent
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Abstract
The invention relates to a process for the preparation of a compound of formula (I) or a salt thereof.
Claims30
A process for the preparation of a compound of formula (I)
- or a salt thereof, wherein a compound of formula (II)
- or a salt thereof is hydrogenated
- (e) in the presence of a catalyst comprising iridium;
- or
- (f) in the presence of a catalyst comprising ruthenium and a compound of:
- formula (IV),
- formula (V),
- formula (VI),
- or formula (VII),
- wherein
- R3 is alkyl, cycloalkyl or aryl;
- R4 is cycloalkyl, aryl or heteroaryl;
- R5 is cycloalkyl or aryl;
- R6 is cycloalkyl or aryl;
- R7 is cycloalkyl or aryl;
- R8 is cycloalkyl or aryl;
- and
- R9 is cycloalkyl or aryl.
15 more elements
Dependencies are inferred from the claim text.