Novel compound having affinity for amyloid
AssigneeNihon Medi-Physics Co., Ltd.
InventorsShigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
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AssigneeNihon Medi-Physics Co., Ltd.
InventorsShigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
Estimating the term…
A compound effective as a probe targeting amyloid for image diagnosis and a reagent comprising the compound for detecting amyloid deposited on a biological tissue are provided. Provided are a compound represented by the following formula (1): wherein R1 is a group selected from the group consisting of a halogen substituent, alkyl substituent with 1 to 4 carbon atoms, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and hydroxyl group, R2 is a group selected from the group consisting of a cyano substituent, alkyl substituent with 1 to 4 carbon atoms and halogen substituent, R3 is a group selected from the group consisting of a hydroxyl group, halogen substituent and substituent represented by the following formula: (wherein R4 is a hydrogen, halogen substituent or hydroxyl group, and m is an integer of 1 to 4), provided that at least one of R1, R2, R3 and R4 represents a radioactive halogen, and a reagent comprising the same.
A compound represented by the following formula (1), or a salt thereof:
A compound represented by the following formula (3), or a salt thereof:
A compound represented by the following formula (5), or a salt thereof:
A compound represented by the following formula (6), or a salt thereof:
A compound represented by the following formula (7), or a salt thereof:
A reagent for detecting amyloid deposited on a biological tissue, which comprises a compound represented by the following formula (1), or a salt thereof:
A reagent for detecting amyloid deposited on a biological tissue, which comprises a compound selected from the group consisting of 2-(4′-fluorophenyl)-6-[123I]iodo-3-methylimidazo[1,2-a]pyridine, 2-[4′-(2″-hydroxyethoxy)phenyl]-6-[123I]iodo-3-methylimidazo[1,2-a]pyridine, 2-(4′-hydroxyphenyl)-6-[123I]iodo-3-methylimidazo[1,2-a]pyridine, 3-cyano-2-[4′-(2″-hydroxyethoxy)phenyl]-6-[123I]iodoimidazo[1,2-a]pyridine, 2-[4′-(2″-[18F]fluoroethoxy)phenyl]-3-iodo-6-methoxyimidazo[1,2-a]pyridine, 2-[4′-(2″-[18F]fluoroethoxy)phenyl]-6-methoxy-3-methylimidazo[1,2-a]pyridine and 2-(4′[18F]fluorophenyl)-6-iodo-3-methylimidazo[1,2-a]pyridine.
Dependencies are inferred from the claim text.