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US 2010/0249398 A1Published application
Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
AssigneeLes Laboratoires Servier
InventorsJean-Louis Peglion, Aimée Dessinges, Bernard Serkiz
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Abstract
Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.
Claims7
A process for the synthesis of the compound of formula (VIII), in racemic or optically active form:
- wherein a compound of formula (II), in racemic or optically active form:
- is reacted with a compound of formula (IX):
- in the presence of a salt of a transition metal or of a lanthanide,
- in a solvent,
- to yield a compound of formula (X), in racemic or optically active form:
- which is converted into the compound of formula (VIII) by the action of a hydride donor agent.
3 more elements
A compound of formula (X), in racemic or optically active form:
Dependencies are inferred from the claim text.