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US 2010/0249397 A1Published application
Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
AssigneeLes Laboratoires Servier
InventorsJean-Louis Peglion, Aimée Dessinges, Bernard Serkiz
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Abstract
Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.
Claims12
A process for the synthesis of the compound of formula (VII), in racemic or optically active form:
- wherein R represents a hydrogen atom or a methyl group,
- wherein a compound of formula (VIII):
- is reacted with a compound of formula (IX), in racemic or optically active form, in the form of the free base or a salt:
- wherein R is as defined hereinbefore,
- in the presence of a salt of a transition metal or of a lanthanide,
- in a solvent,
- to yield a compound of formula (X), in racemic or optically active form:
- which is converted into a compound of formula (VII) by the action of a hydride donor agent.
5 more elements
A compound of formula (VIII):
A compound of formula (X), in racemic or optically active form:
- wherein R represents a hydrogen atom or a methyl group.
Dependencies are inferred from the claim text.