MODIFIED Fc MOLECULES
AssigneeXencor, Inc.
InventorsJOHN R. DESJARLAIS, SHER BAHADUR KARKI, GREGORY ALAN LAZAR, JOHN O. RICHARDS, GREGORY L. MOORE, DAVID F. CARMICHAEL
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Abstract
The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.
Claims1
An Fc variant of a parent Fc polypeptide comprising at least a first and a second substitution, said first and second substitutions each at a position selected from group consisting of 234, 235, 236, 239, 267, 268, 293, 295, 324, 327, 328, 330, and 332, wherein said Fc variant exhibits an increase in affinity for one or more receptors selected from the group consisting of FcγRI, FcγRIIa, and FcγRIIIa as compared to the increase in a affinity of said Fc variant for the FcγRIIb receptor, wherein the numbering is according to the EU index and wherein said increases in affinities are relative to said parent polypeptide.
Dependencies are inferred from the claim text.