Bis(thio-hydrazide amide) formulation
AssigneeSynta Pharmaceuticals Corp.
InventorsWalter J. Lunsmann, Ninad Deshpanday
Life of this patent
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Abstract
Disclosed herein are compositions comprising a compound represented by structural formula (I): 2 g of which is reconstitutable in 10 mL of a water in less than 10 minutes, and methods for preparing these compositions. Also disclosed are compositions comprising a compound represented by structural formula (I) and a pharmaceutically acceptable excipient, wherein the molar ratio of said compound to said excipient is from 1:20 to 1:1, and methods for preparing these compositions.
Claims25
A composition comprising a compound represented by the following structural formula:
- wherein:
- Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group;
- R1-R4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring;
- Z is —O or —S;
- and
- M+ is a pharmaceutically acceptable monovalent cation and M2+ is a pharmaceutically acceptable divalent cation;
- and
- wherein 2 g of said composition is reconstitutable in 10 mL of a water in less than 10 minutes.
A composition comprising a compound represented by the following structural formula:
- wherein:
- Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group;
- R1-R4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring;
- Z is —O or —S;
- and
- M+ is a pharmaceutically acceptable monovalent cation and M2+ is a pharmaceutically acceptable divalent cation;
- and
- a pharmaceutically acceptable excipient, wherein the molar ratio of said compound to said excipient is from 1:20 to 1:1.
25-103. (canceled)
Dependencies are inferred from the claim text.