Non-Steroidal Anti-Inflammatory Drug Dosing Regimen
AssigneeJohnson & Johnson Consumer Inc.
InventorsCathy K. Gelotte, Douglas R. Hough, Gerard P. McNally
Life of this patent
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Abstract
A method of administering non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, or acetaminophen is provided. This method provides improved therapeutic effect, in particular pain relief, over extended time periods.
Claims31
A method of administering a non-steroidal anti-inflammatory drug, which consists of providing to a mammal an initial dose of said non-steroidal anti-inflammatory drug followed by a second dose of said non-steroidal anti-inflammatory drug about 3 to 5 hours after administration of said initial dose, said non-steroidal anti-inflammatory drug having a duration of therapeutic effect which lasts at least about 6 hours after administration of said second dose.
A method of administering a propionic acid derivative to a mammal, over a 12-hour time period, which comprises providing a first peak plasma concentration of said propionic acid derivative of about 25 to about 30 mcg/mL in said mammal about 30 to about 120 minutes after said initial dose, and a second peak plasma concentration of said propionic acid derivative of about 15 to about 30 mcg/mL about 4.5 to about 5.5 hours after administration of said initial dose.
A method of administering a propionic acid derivative, which comprises providing to a mammal, over a 12 hour time period, an initial dose of said propionic acid derivative at the beginning of said 12 hour time period, followed by a second dose of said propionic acid derivative about 3 to 5 hours after administration of said initial dose, wherein said initial dose is at least about twice said second dose and no further propionic acid derivative is provided during said 12 hour time period.
-23. (canceled)
A method of administering acetaminophen, which consists of providing to a mammal an initial dose of acetaminophen followed by a second dose of acetaminophen about 3 to 5 hours after administration of said initial dose, said acetaminophen having a duration of therapeutic effect which lasts at least about 6 hours after administration of said second dose.
A method of administering acetaminophen, which comprises providing to a mammal, over a 12 hour time period, an initial dose of acetaminophen at the beginning of said 12 hour time period, followed by a second dose of acetaminophen about 3 to 5 hours after administration of said initial dose, wherein said initial dose is at least about twice said second dose and no further acetaminophen is provided during said 12 hour time period.
-34. (canceled)
A method of administering a therapeutic agent, which consists of providing to a mammal an initial dose of a non-steroidal anti-inflammatory drug followed by a second dose of acetaminophen about 3 to 5 hours after administration of said initial dose of non-steroidal anti-inflammatory drug;
- said non-steroidal anti-inflammatory drug and acetaminophen having a combined duration of therapeutic analgesic effect which lasts at least about 6 hours after administration of said second dose of acetaminophen.
Dependencies are inferred from the claim text.