Compound and use thereof in the treatment of amyloidosis

Agent for stabilising the tetrameric form of transthyretin, which comprises a compound of the general formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof:

• wherein:
• each Y is independently a direct bond or —CH2—;
• each X is independently —NH—, —O—, —S—, —CH2—, —NR—, —CO—, —CONH—, —CONR—, —C═N—O—, —NHCO—, —NRCO—, —O—N═C—, —SO—, —SO2— or a direct bond, wherein
• each of R1, R2, R3 and R4 is independently F, Cl, Br, I, CF3, OCF3, R′, OR′, NR′R′, SOR′ or SO2R′,
• wherein R and R′ are each independently C1-C3alkyl which is straight or branched chain or cyclic optionally substituted by one or more halogen atoms;
• and each m, n, p and q is independently 0 to 4, wherein m+n+p+q>0;
• and wherein the linker is a linear or branched chain of 7 to 13 carbon atoms in which one or more of the carbon atoms are optionally replaced by a heteroatom, wherein the said chain is unsubstituted or substituted by one or more groups comprising halogen, O, or N atoms, or OH, C1-C3 alkyl, C2-C3 alkenyl, C2-C3 alkynyl or C1-C3 alkoxy.